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Increase Your Awareness with Basic Facts about Brexpiprazole (Rexulti®)
Nikki and Anne Heart ♥ September 1, 2026
*Picture displayed are of general pills and should not be used as a pill identifier.
The following highlights the facts. More information can be obtained through the sites listed below as well as many other informational sites regarding prescription and over-the-counter drugs. Medication facts can change. Make sure you have all up-to-date information.
Quick facts YOU Need to Know
Brexpiprazole, brand names:
- Rexulti®
Brexpiprazole is in a class of medications called atypical antipsychotic.
Brexprazole is used to treat:
- schizophrenia (a mental illness that affects how a person thinks, feels and behaves)
- depression, along with another antidepressant medication
- agitation in people with dementia due to Alzheimer’s disease
Brexpiprazole may cause side effects such as:
- drowsiness
- tiredness
- dizziness
- feeling unsteady or having trouble keeping your balance
Some side effects can be serious. If you experience any of the following symptoms, call your healthcare provider immediately:
- rash
- hives
- itching
- swelling of the eyes, face, mouth, lips, tongue, throat, hands, feet, ankles, or lower legs
- difficulty breathing or swallowing
- seizures
- sore throat
- cough
- fever
- chills
- difficult, painful urination or other signs of infection
- sweating
- confusion
- fast or irregular heartbeat
- severe muscle stiffness
- unusual movements of your face or body that you cannot control
- feeling unsteady, or having trouble keeping your balance, falling down
- tightening of the neck muscles or throat, difficulty swallowing
Brexpiprazole may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Rexulti® may have different side effects. Check Resulti® medication guide for complete information.
IMPORTANT WARNING:
Important warning for older adults with dementia:
Older adults with dementia (loss of memory and brain function) may have an increased chance of death if treated with an antipsychotic medication such as brexpiprazole. Older adults with dementia may also have an increased risk of having a stroke or ministroke during treatment with antipsychotics.
Brexpiprazole is not approved by the Food and Drug Administration (FDA) for the treatment of psychosis (loss of touch with reality) without agitation in older adults with dementia due to Alzheimer’s disease. Talk to the doctor who prescribed this medication if you, a family member, or someone you care for has dementia and is taking brexpiprazole.
Important warning for people who have depression:
Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses have a greater risk of becoming suicidal. This is especially of concern at the beginning of your treatment and any time that your dose is changed. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; new or worsening anxiety; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; and mania (frenzied, abnormally excited mood). Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own.
You will be given the Medication Guide. Read the information carefully and ask your doctor or pharmacist if you have any questions. You can also visit https://www.fda.gov/Drugs/DrugSafety/ucm085729.htm to obtain the Medication Guide.
Talk to your doctor about the risk(s) of taking brexpiprazole.
Important Warning
(Rexulti® Medication Guide)
- Increased risk of death in elderly people with dementia-related psychosis. Medicines like REXULTI can raise the risk of death in elderly people who have lost touch with reality (psychosis) due to confusion and memory loss (dementia). REXULTI is not approved for the treatment of people with dementia-related psychosis without agitation that may happen with dementia due to Alzheimer’s disease.
- Increased risk of suicidal thoughts and actions. REXULTI and antidepressant medicines may increase suicidal thoughts and actions in pediatric patients and young adult patients, especially within the first few months of treatment or when the dose is changed. Depression and other mental illnesses are the most important causes of suicidal thoughts and actions. All patients on antidepressants and their families or caregivers should closely watch for new or worsening depression symptoms, especially sudden changes in mood, behaviors, thoughts, or feelings. Report any change in these symptoms immediately to the doctor.
Special precautions to know before taking Brexpiprazole
- Know list of ingredients for potential allergic reactions
- Discuss all medications you are currently on or have recently stopped with your health care provider
- Be aware that nonprescription and herbal products may have interactions, including St. John’s wort
- Tell your health care provider regarding any health problems you have or had in the past
- Inform your health care provider of any heart conditions current or past
- Notify your doctor if you are pregnant, plan on becoming pregnant or breast feeding
- You may become drowsy and may affect your ability to think clearly and react quickly
- Do not drive or operate hazardous machinery and take precautions to avoid falls until you know how this medication affects you
- This medication may increase your blood sugar
- It may become harder for your body to cool down
- Increased weight gain may occur
Some people may develop gambling problems or other intense urges or behaviors that are compulsive or unusual for them, such as increased sexual urges or behaviors, excessive shopping, and binge eating when taking Brexpiprazole.
Sources used:
- Medication Guide, Rexulti, accessed August 27, 2026
- MedlinePlus, Brexpiprazole, accessed August 27, 2026
- Rexulti.com, Rexulti, accessed August 26, 2026
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Medical Disclaimer: We share informational resources that are intended to help you with your self-care plan. We are not professionals. We write based on personal experience and personal research.
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