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Increase Your Awareness with Basic Facts About Gepirone
Nikki and Anne Heart ♥ July 21, 2026
*Picture displayed are of general pills and should not be used as a pill identifier.
The following highlights the facts. More information can be obtained through the sites listed below as well as many other informational sites regarding prescription and over-the-counter drugs. Medication facts can change. Make sure you have all up-to-date information.
Important
Gepirone has been discontinued in the US.
Because this drug is no longer available in the US market, the material on this page has not been updated. If this drug is used in countries other than the U.S., it is essential that the manufacturers’ labeling be consulted for more recently available information.
The following information is basic facts before Gepirone was discontinued. Therefore, this information is not-up-to-date. Please check any up-to-date medical guidelines from your prescriber.
Gepirone, brand names: Exxua®
Gepironte, class of medications called serotonin modulators
Gepirone, swallow the tablets whole; do not split, chew or crush them
Gepirone, used to treat depression in adults, but is not a cure
Possible side effects of Gepirone:
- dizziness
- headache
- sleepiness
- unusual tiredness
- dry mouth
- stomach pain
- heartburn
- increased appetite
- increased weight
- constipation
- sore throat, runny or stuffy nose, cough, or fever
- numbness or tingling in the hands, feet, arms, or legs
- rash, itching, or hives
Some side effects can be serious. If you experience any of the following symptoms, call your healthcare provider immediately:
- seizures
- fever, sweating, confusion, fast or irregular heartbeat, severe muscle stiffness or twitching, agitation, hallucinations, loss of coordination, nausea, vomiting, or diarrhea
- seizures
Gepirone may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.
Important Warning
A small number of children, teenagers, and young adults (up to 24 years of age) who took antidepressants (‘mood elevators’) such as gepirone during clinical studies became suicidal (thinking about harming or killing oneself or planning or trying to do so). Children, teenagers, and young adults who take antidepressants to treat depression or other mental illnesses may be more likely to become suicidal than children, teenagers, and young adults who do not take antidepressants to treat these conditions. However, experts are not sure about how great this risk is and how much it should be considered in deciding whether a child or teenager should take an antidepressant. Children younger than 18 years of age should not normally take gepirone, but in some cases, a doctor may decide that gepirone is the best medication to treat a child’s condition.
You should know that your mental health may change in unexpected ways when you take gepirone or other antidepressants even if you are an adult over 24 years of age. You may become suicidal, especially at the beginning of your treatment and any time that your dose is increased or decreased. You, your family, or your caregiver should call your doctor right away if you experience any of the following symptoms: new or worsening depression; thinking about harming or killing yourself, or planning or trying to do so; extreme worry; agitation; panic attacks; difficulty falling asleep or staying asleep; aggressive behavior; irritability; acting without thinking; severe restlessness; or frenzied abnormal excitement. Be sure that your family or caregiver knows which symptoms may be serious so they can call the doctor if you are unable to seek treatment on your own. Your healthcare provider will want to see you often while you are taking gepirone, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.
Your healthcare provider will want to see you often, especially at the beginning of your treatment. Be sure to keep all appointments for office visits with your doctor.
Special precautions to know before taking Gepirone
- Know list of ingredients for potential allergic reactions
- Discuss all medications you are currently on or have recently stopped with your health care provider
- Be aware that nonprescription and herbal products may have interactions
- Tell your health care provider regarding any health problems you have or had in the past
- Inform your health care provider of any heart conditions current or past
- Notify your doctor if you are pregnant, plan on becoming pregnant or breast feeding
- Question whether you can eat or drink grapefruit
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Medical Disclaimer: We share informational resources that are intended to help you with your self-care plan. We are not professionals. We write based on personal experience and personal research.
Nothing on this Website is intended to be taken as medical advice. The information provided on the Website is intended to encourage, not replace, direct patient-health professional relationships. Always consult with your doctor before altering your medications. Adding nutritional supplements may alter the effect of medication. Any medication changes should be done only after proper evaluation and under medical supervision.
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